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. 2020 Aug 19;8:1011. doi: 10.3389/fbioe.2020.01011

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Copyright © 2020 Frieboes, Raghavan and Godin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transport characteristics in breast cancer liver metastases. (A) Perfusion and diffusion of 3 KDa (red) and 40 KDa (green) fluorescent dextrans by IVM in normal liver (upper panels) and 4T1 breast cancer liver metastases after iv injection. (B) Fluorescent intensities of the dextrans in breast cancer liver metastases normalized to unaffected liver. (C) Distribution of Mϕ (F4/80 antibody, green) in breast cancer liver metastases. Number of Mϕ in the lesion, the periphery (40–50 micron from the tumor border) and unaffected liver is normalized to cell number detected by DAPI staining. Reprinted with permission from Tanei et al. (2016).