FIGURE 2.

Therapeutic efficacy and survival of mice bearing breast cancer liver metastases following IV administration of MSV-nAb-PTX, or nAb-PTX. (A) Kaplan–Meier survival curves. Mice were injected intrasplenically with cancer cells and therapy was initiated 1 week later. Therapy was administered every 5 days until animals were moribund (Log-rank test for MSV-nAb-PTX vs. nAb-PTX is P < 0.05 for 4T1 and P < 0.01 for 3LL models, respectively). (B) Quantitative analysis of proliferating Ki67-positive cancer cells. (C) Quantification of tumor diameters in mice liver treated with the systems. (D) Apoptotic TUNEL-positive cancer cells. Reprinted with permission from Tanei et al. (2016).