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. 2020 Aug 17;10(8):1613. doi: 10.3390/nano10081613

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Representative materials with acid-labile bond cleavage or degradation for cancer immunotherapy. (a) ALG = OVA: ovalbumin-conjugated alginate; (b) GDR: galactosyl dextran-retinal conjugates; (c) CART D13:A11: charge-altering releasable transporter with 13 carbonate repeating units and 11 amino ester repeating units; (d) PEG2000-hydrazone-C18: conjugates of polyethylene glycol (molecular weight of 2000) and stearic hydrazide; (e) PEG-CDM-PDEA: conjugates of PEG and poly(2-(diethylamino) ethyl methacrylate with 2-propionic-3-methylmaleic anhydride linkers; (f) DiPt-ASlink-PEG_2k: conjugates of PEG2000 and hexadecyl-oxaliplatin(IV) with 2-propionic-3-methylmaleic anhydride linkers; (g) PEG = TMC-Man: PEG and mannose doubly modified trimethyl chitosan; PAH-Cit (PC): citraconic anhydride-grafted poly (allylamine hydrochloride); (h) HA-ADH-DOX: conjugates of hyaluronic acid and doxorubicin with hydrazine linkers; (i) PLGA: poly(lactic-co-glycolic acid); (j) PLGA-NaHCO₃/NH₄HCO₃ NP: NaHCO₃ or NH₄HCO₃-encapsulated PLGA nanoparticle; and (k) MOF: Metal-organic framework. The acid-labile groups are indicated in red.