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. 2020 Aug 19;11:1285. doi: 10.3389/fphar.2020.01285

Figure 4.

Figure 4

PPARγ 3RA mutations exacerbate HFD-induced insulin resistance in mice. Oral glucose tolerance test (OGTT) (A) and intraperitoneal insulin tolerance test (IPITT) (B) of 8-week old PPARγ3RA/+ and WT littermates with chow diet. From 8 weeks age, mice were fed with HFD for 15 weeks. Fasting blood glucose (C) and insulin (D) levels of mice fed with HFD. OGTT (E) and IPITT (F) of mice fed with HFD for 15 weeks. For (C, D), values are means ± SEM, n=6 per group, *p < 0.05, **p < 0.01 by Student’s t test.