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. 2020 Aug 19;11:1285. doi: 10.3389/fphar.2020.01285

Figure 5.

Figure 5

Metabolic disorders in HFD-fed PPARγ3RA/+ mice were improved by rosiglitazone treatment. 8-week old male PPARγ3RA/+ and WT littermates were fed with HFD for 15 weeks, and then i.p. injected with 3 mg/kg of rosiglitazone once daily for 6 days. (A–F) Fasting serum levels of TCHO (A), TG (B) FFA (C), LDL-C (D) HDL-C (E) and glucose (F). (G) Representative images of H&E stained BAT and iWAT (original magnification, 200×). (H) Quantitative statistics of adipose cell size in (G). (I) Representative images of H&E stained liver sections (original magnification: top, 100×; bottom, 200×). (J) mRNA levels of PPARγ direct target genes involved in glucose and lipid metabolism in liver tissues of mice. For (A–F, J), measurement were repeated three times with similar results. Data show a representative experiment. Values are means ± SEM, n=6 per group, *p < 0.05, **p < 0.01 and ***p < 0.001 by one-way ANOVA followed by the Dunn’s test.