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. 2020 Aug 19;11:1249. doi: 10.3389/fphar.2020.01249

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Copyright © 2020 Cai, Ye, Li, Chen, Wang, Yong, Pan, Lu, Tang, Miao, Snijders, Mao, Liu, Lu and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transplantation of the resveratrol-modified fecal microbial community improved intestinal characteristics and decreased inflammatory response in db/db mice. (A) Representative photomicrographs of H&E-stained small intestine sections and immunofluorescence for ZO-1, Claudlin-1, IFN-γ and TNF-α (magnification: 200×). (B) Representative histological scoring of small intestine damage. (C) Plasma FITC-dextran 4 (DX, 4,000 molecular weight) levels after oral challenge in control post-FMT (n=8) or resveratrol post-FMT (n=8) mice. (D) Plasma levels of LPS (endotoxin units/ml). (E–H) Serum levels of TNF-α, IFN-γ, IL-6, and IL-1β by ELISA in control post-FMT (n=8) or resveratrol post-FMT (n=8). ***p<0.001; **p<0.01; *p<0.05; and ns: not significant.