TABLE 1.

Characteristics of three major subtypes of EVs.

EV	Size	Shape	Marker	Origin
Exosome	40–120 nm	Round	Tetraspanins, Alix, TSG101, PDCD6IP, flotillin, MFGE8	Endolysosomal pathway
Microvesicle	50–1000 nm	Irregular	Integrins, MMPs, selectins, CD40	Plasma membrane
Apoptotic body	500–2000 nm	Heterogeneous	Phosphatidylserine, genomic DNA	Plasma membrane, endoplasmic reticulum