Table 8.

Comparison of Absolute Change in Mean OCS Scores Between Active and Sham Treatment by Correct vs. Incorrect Hemisphere.

Statistic	Active Correct	Active Incorrect	Active Difference (Correct - Incorrect)	Sham Correct	Sham Incorrect	Sham Difference (Correct - Incorrect)	Difference of Differences (Active - Sham)
n	20	20	20	20	20	20	20
Mean (SD)	−2.3 (2.6)	−1.6 (2.2)	−0.7 (1.3)	−2.1 (2.2)	−1.9 (1.9)	−0.2 (1.4)	−0.5 (1.2)
Median	−2.7	−1.7	−0.3	−1.3	−2.0	0.0	−0.2
Min, Max	−8.0, 2.0	−6.0, 2.7	−4.7, 1.0	−7.3, 0.7	−6.7, 0.7	−5.0, 2.3	−2.7, 1.7
95% CI	(−3.5, −1.0)	(−2.6, −0.6)	(−1.2, −0.1)	(−3.1, −1.1)	(−2.8, −1.0)	(−0.8, 0.5)	(−1.0, 0.1)
p-value (paired t-test)			0.0155			0.2836	0.0431
p-value (signed-rank test)			0.0087			0.4462	0.0437

All Randomized Patients with Complete Data

[1] Wilcoxon signed-rank tests were performed to assess change from baseline in the OCS score on the correct and incorrect hemispheres after active treatment and sham treatment on the same day, separately. The correct and incorrect hemispheres were based on a computer test for emotional valance.

[2] The baseline score used to calculate absolute change corresponded to the pre-treatment score the week they received the assigned treatment. For patients who received active treatment at week 1, the baseline score from week 1 was used. For patients who received active treatment at week 2, the baseline score from week 2 was used. The baseline for sham treatment was derived in a similar way.

[3] A Wilcoxon signed-rank test was performed to compare the difference in absolute change from baseline in the OCS score on active treatment versus sham treatment (Difference of Differences column).

[4] One-sided lower p-values were calculated for all tests.