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. 2020 Aug 19;8:753. doi: 10.3389/fcell.2020.00753

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Copyright © 2020 Tumia, Wang, Dong, Ma, Beebe, Chen, Dong, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of eukaryotic initiation factor (eIF)3a in non-homologous end joining (NHEJ) repair of ionizing radiation (IR)-induced double-strand breaks (DSBs). (A,B) Comet assay was used to determine eIF3a effects on the level of DSBs induced by IR in H1299 cells with transient eIF3a knockdown (A) and NIH3T3 cells with stable eIF3a overexpression (B) compared with their respective control cells. The histograms show the summary of quantitative analysis of Olive tail moment in these cells. (C,D) Host cell reactivation assays using reporter constructs were performed using H1299 cells with eIF3a knockdown (C) and NIH3T3 cells with eIF3a stable overexpression (D) compared with their respective control cells (n = 3; **P < 0.01).