Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypothetical model of eukaryotic initiation factor (eIF)3a regulation of DNA repair protein synthesis relationship with DNA damage resistance and tumorigenesis. Binding of eIF3a to 5′-untranslated regions (5′-UTRs) of mRNAs encoding DNA damage repair proteins inhibits translation and synthesis of DNA repair proteins, leading to sensitization of cancer cells to DNA-damaging treatments and susceptibility of normal cells to DNA-damaging carcinogens.
