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. 2020 Sep 2;12:77. doi: 10.1186/s13073-020-00773-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LINC00301 is up-regulated in both human NSCLC tumorous tissues and cell lines and is beneficial to NSCLC prognosis. a, b Exploring LINC00301 expression in NSCLC cell lines by assembling the Cancer Cell Line Encyclopedia (CCLE) (www.broadinstitute.org/ccle). c LINC00301 expression in NSCLC cell lines and 16HBE/BEAS-2B cells. d, e LINC00301 expression in NSCLC tumor tissues and adjacent normal lung tissues. g According to LINC00301 expression, 120 NSCLC patients were divided into high (n = 60) and low (n = 60) LINC00301 groups. h Kaplan-Meier survival analysis showed that high expression of LINC00301 was correlated with worse prognosis in NSCLC patients. *p < 0.05, means ± SD was shown. Statistical analysis was performed by Student’s t-test and the log-rank test. i, j Correlation between the LINC00301 RNA level and the survival of NSCLC patients from 2437 lung tumors using Kaplan-Meier plotter datasets (2015 version) (http://kmplot.com/analysis/index.php?p=service&cancer=lung)