Fig. 5.

miR-155 is critical for CD8⁺ BT_RM accumulation in the CNS during neuroinvasive infection. Male (14d) or male and female (28d) C57BL/6J mice were infected with 2.0 × 10⁵ CFU Lm EGD, then treated with antibiotics beginning 2d p.i. a Mice were injected s.c. with miR-155 inhibitor (black upward-pointing triangle) or LNA scramble (white upward-pointing triangle) was injected s.c. on 2d, 4d, 6d, and 8d p.i. then sacrificed on 14d (b–e) or 28d (f–k) p.i. Brain leukocytes were analyzed by FACS. n = 8–9 (14d) or 4–5 (28d) for each sex and treatment. Symbols represent individual mice. Significance was calculated via two-tailed Student’s t test