Table 2.

Treatment-Emergent Adverse Events Occurring in > 15% of Patients

	Number (%) of patients Total N=46
Preferred Term	Any grade	Grade ≤ 3
Patients with any AE	46 (100)	39 (84.8)
Fatigue	30 (65.2)	3 (6.5)
Neutropenia	26 (56.5)	20 (43.5)
Thrombocytopenia	23(50)	11 (23.9)
Nausea	22 (47.8)	0 (0)
Diarrhea	21 (45.7)	2 (4.3)
Decreased appetite	19 (41.3)	0 (0)
Hypertension	19 (41.3)	15 (32.6)
Vomiting	18 (39.1)	0 (0)
Anemia	16 (34.8)	9 (19.6)
Constipation	15 (32.6)	0 (0)
Weight decreased	9 (19.6)	0 (0)
Arthralgia	8 (17.4)	0 (0)
Back pain	8 (17.4)	0 (0)
Dyspnea	8 (17.4)	2 (4.3)
Abdominal pain	7 (15.2)	1 (2.2)
Asthenia	7 (15.2)	0 (0)
Cough	7 (15.2)	0 (0)