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Pharmacokinetics of ME-344
| Pharmacokinetic Parameters | Arithmetic Mean | SD |
|---|---|---|
| Cmax (ng/mL) | 20880 | 8201.3 |
| Cmin (ng/mL) | 25.30 | 12.824 |
| tmax (hr) | 0.500 | 0.48, 2.02 |
| AUC0−t (hr*ng/mL) | 21830 | 6565.4 |
| AUC0−inf (hr*ng/mL) | 22040 | 6563 |
| AUC%extrap (%) | 1.03 | 0.830 |
| t1/2 (hr) | 5.301 | 2.0114 |
| kel (1/hr) | 0.1440 | 0.039468 |
| CL,ss (L/hr) | 42.593 | 33.4433 |
| Vd,ss (L) | 104.648 | 121.4296 |
| CL,ss/kg (L/hr) | 0.505 | 0.2450 |
| Vd,ss/kg (L) | 1.200 | 0.9511 |
