Table 1.
Patients characteristics of the RT-qPCR retrospective validation cohort (n = 145).
| Parameter | Percentage (n) | |
|---|---|---|
| Gender | female | 39% (57) |
| male | 61% (88) | |
| Age | 63.8 ± 13.99 (mean ± SD) | |
| Alcohol abuse (n = 121) | absent | 60% (73) |
| present | 40% (48) | |
| Tobacco (n = 137) | non smoker | 43% (59) |
| smoker | 57% (78) | |
| T stage | T1 | 12% (18) |
| T2 | 23% (34) | |
| T3 | 40% (58) | |
| T4 | 24% (35) | |
| N stage | N0 | 51% (74) |
| N1 | 11% (16) | |
| N2 | 16% (23) | |
| N3 | 22% (32) | |
| Stage | I | 11% (16) |
| II | 17% (24) | |
| III | 20% (29) | |
| IVA | 30% (43) | |
| IVB | 23% (33) | |
| Differentiation | verrucous | 3% (5) |
| well | 70% (102) | |
| moderate | 20% (29) | |
| poorly | 6% (8) | |
| basaloid | 1% (1) | |
| Mitotic Index (n = 119) | high | 40% (48) |
| low | 33% (39) | |
| mid | 27% (32) | |
| Perineural invasion (n = 125) | absent | 48% (60) |
| present | 52% (65) | |
| Lymphovascular invasion (n = 126) | absent | 61% (77) |
| present | 39% (49) | |
| ENE | absent | 73% (106) |
| present | 27% (39) | |
| Margins | negative or close | 83% (120) |
| positive | 17% (25) | |
| HPV | negative | 96% (139) |
| positive | 4% (6) | |
| Adjuvant treatment | none | 41% (59) |
| RT | 40% (58) | |
| RT + CT or Cetuximab | 19% (27) | |
| curietherapy | 1% (1) | |
| Recurrence | absent | 61% (88) |
| local | 23% (33) | |
| regional | 19% (27) | |
| metastatic | 13% (19) | |
| Severity | non-severe | 74% (107) |
| severe | 26% (38) | |
Numbers in brackets beside clinical parameters indicate the number of patients for which the information was available.