Figure 4.

Alterations of hyperalgesia in animal groups with blue laser stimulation. (A) Paw withdrawal latency scores, (B) paw withdrawal threshold scores, and (C) thermal latency scores of all eight animal groups. Only CCD-Opto-shPKCγ group (a) and CCD-Opto-shPKCsafe group (e) exhibited significant changes of behavioral scores with blue light “ON” state. In other animal groups, blue laser stimulation “ON” state did not have any significant alterations in behavioral response. *p < 0.05; **p < 0.01, ***p < 0.001 significant difference between the indicated values (ANOVA).

CCD: chronic compression of dorsal root ganglion; PKCγ: protein kinase C gamma.