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. Author manuscript; available in PMC: 2020 Sep 2.
Published in final edited form as: Horm Behav. 2019 Jul 20;114:104541. doi: 10.1016/j.yhbeh.2019.06.005

Fig. 4.

Fig. 4.

Prolonged single housing alters MR gene regulation and the MR/GR ratio in the CA2 subregion of the HPC. (A) Both SH7 and SH14 mice show a downregulation in MR gene expression in the dorsal HPC from AM to PM; the CA2 region is shown. However, SH14 mice sacrificed in the PM exhibit lower MR mRNA levels than SH7 mice sacrificed in the AM. (B) SH7 mice exhibit a significant decrease from AM to PM in the MR/GR mRNA ratio in the CA2 subregion of the dorsal HPC, in contrast to the SH14 mice that show little change from AM to PM. SH14 mice exhibit significantly lower and higher MR/GR ratios in the AM and PM, respectively, compared to SH7 mice. Data represent mean ± SEM. **p < 0.01; ***p < 0.001.