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. 2020 Sep 2:10.2217/epi-2020-0162. doi: 10.2217/epi-2020-0162

Figure 1. Alignment of 5'UTR regions of three coronaviruses.

Figure 1.

Alignment of (A) the first part (100 nucleotides) of the 5’UTR of three coronavirus isolates that show the similarity of the leader sequence (colored in green and blue) and the IGS depicted in brown. The position 56, considered crucial for viral transcription is represented in red. Blue and black lines indicate the genomic regions where siRNAs reported in the literature have been designed; (B) the alignment of complete 5’UTR region showing the similitude of the leader sequences and the high conservation of the transcription-regulatory sequence in SARS-CoV and SARS-CoV-2.

IGS: Intergenic sequence; SARS-CoV: Severe acute respiratory syndrome coronavirus; SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; TRS: Transcription-regulatory sequence.