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. 2020 Jul 31;10(9):2999–3008. doi: 10.1534/g3.120.401545

Figure 3.

Figure 3

STRING interactome analysis of potential interactors of EGFR and YKi in Drosophila. STRING analysis was performed with confidence score of 0.7 and MCL clustering value of 2. (A) STRING Interactome of 73 fly genes identified as potential negative regulators in the context of over expression of EGFR. 17 out of those formed molecular clusters (with PPI enrichment value of 0.000482), largest being a cluster of 6 genes, all of which are constitutes of Fat/Hippo pathway (shown in red; FDR-1.39E-5). (B) STRING Interactome of 888 genes of identified as potential negative regulators in the context of over expression of Yki. 228 of those formed a single cluster with PPI enrichment value 1.4E-06. Components of Fat/Hippo pathway (red: FDR-0.00076) and Autophagy genes (blue: FDR-0.0241) are enriched in this cluster. (C) STRING Interactome of 32 fly genes identified as potential oncogenes in the context of SOCS suppression. 27 out of those formed molecular clusters (with PPI enrichment value of 0.0122), largest being a cluster of 14 genes. A smaller cluster comprising of EGFR and DrK were enriched in Dorso-ventral axis formation (shown in purple: FDR-0.0089).