Extended Data Fig. 8. Single cell transcriptomics defines distinct expression signatures in primary B-ALL cells.

(a.) Clustering of bone marrow cells from a prednisolone sensitive patient (n=2,427 control cells; n= 924 treated cells) based on top 1000 most highly expressed genes (b.) Identification of distinct cell populations in a prednisolone sensitive patient CD19+ B-cells (red), CD3E+ T-cells (blue), ALAS2+ Erythrocytes (purple) and CD14+ Macrophages (green) (c.) Control vs. treatment for all cell clusters in prednisolone sensitive patient (red = control, blue = treated) (d.) Clustering of bone marrow cells from a prednisolone resistant patient (n= 686 control cells; n=759 treated cells) based on top 1000 most highly expressed genes (e.) Identification of distinct cell populations in a prednisolone resistant patient CD19+ (red) and CD3E+ T-cells (blue) (f.) Control (C) vs. treatment (T) for all cell clusters in prednisolone resistant patient (red = control, blue = treated)