Table 6.
Coagulation laboratory values before and after low dose heparinized saline protocol initiation.
| Lab valuea | No systemic anticoagulation (n = 16) |
Systemic anticoagulation (n = 14) |
||||
|---|---|---|---|---|---|---|
| Before | After | p value | Before | After | p value | |
| INR | 1.2 (1.1, 1.3) | 1.2 (1.1, 1.4) | 0.29 | 1.2 (1.1, 1.2) | 1.2 (1.1, 1.2) | 0.69 |
| PTT (seconds) | 40 (34, 53) | 48 (31, 76) | 0.07 | 33 (31, 38) | 32 (29, 38) | 0.45 |
| Fibrinogen (mg/dL) | 650 (579, 840) | 735 (648, 803) | 0.38 | 864 (632, 927) | 731 (640, 892) | 0.22 |
| Anti-Xab (IU/mL) | 0.46 (0.23, 0.59) | 0.62 (0.28, 0.9) | 1 | – | – | – |
| Platelets (K/uL) | 262 (168, 311) | 207 (168, 315) | 0.23 | 325 (205, 441) | 317 (190, 447) | 0.61 |
| CRP (mg/L) | 145 (129, 190) | 149 (133, 288) | 0.18 | 147 (67, 205) | 145 (127, 257) | 1 |
| D-Dimer (ng/mL) | 2464 (1290, 3982) | 2732 (1971, 5951) | 1 | 3289 (925, 4607) | 2716 (1458, 5271) | 1 |
| Ferritin (mcg/L) | 1862 (581, 3011) | 2475 (1265, 3525) | 0.75 | 1404 (920, 2629) | 880 (665, 1547) | 0.11 |
Abbreviations: CRP = C-Reactive Protein; INR = International Normalized Ratio; IQR = Interquartile Range; PTT = Partial Thromboplastin Time.
a
Data presented as median (interquartile range) unless otherwise specified.
b
Patients on systemic enoxaparin versus heparin often had different anti-Xa goals.