Table 2.

Ongoing clinical trials registered on clinicaltrials.gov exploring hydroxychloroquine, methotrexate and colchicine for coronavirus disease 19

Drug	Number of trials registered as of 19th August, 2020	Aspects being explored
Hydroxychloroquine	229	Use of this drug alone or in combination of other agents, or compared to other agents (eg. lopinavir/ritonavir, oseltamivir, favipiravir) for treatment of mild or severe COVID-19
		Chemoprophylaxis in contacts, health care workers
		Reduction of progression to severe disease/ prevention of hospitalization in milder COVID-19
Methotrexate	3	Treatment of severe COVID-19 with methotrexate-containing nanoparticles
		Risk of COVID-19 in patients with rheumatic diseases on drugs like methotrexate
Colchicine	19	Treatment of mild or severe COVID-19
		Prevention of progression of mild COVID-19 to severe disease
		Treatment of myocardial injury in the context of COVID-19

COVID-19 coronavirus disease 19