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Protein motifs favouring extended patches of cholesterol. (a) A sub-membrane helix which sterically entraps cholesterol by disallowing access of large phospholipid headgroups. (b) A TM helix which has an affinity for cholesterol and tilts outward into the lipids. (c), (d) Interacting proteins (green and blue) which share these motifs, leading to the formation of bridging microdomains.
