Figure 4.

Model validation by mutational and cross-linking data. (a) 30 nonbenign human mutations mapped to our model of FAcc. All interface mutations are marked with magenta spheres; non-interface mutations are marked with tan spheres. (b) Close-up renderings of cross-links throughout the FAcc model. Black lines indicate cross-links that are satisfied (<30 Å) by the final refined structure. Representatives from each cross-link cluster are shown for the middle lobe (left) and the bottom lobe (right).