Table 1. Proportion of glycan feature variability in 14 countries explained by linear mixed model, with age and sex defined as fixed effects and country of residence as a random effect.

IgG subclass	Glycan feature	Percentage of glycan trait variability explained by country of residence (%)	Percentage of glycan trait variability explained by age (%)	Percentage of glycan trait variability explained by sex (%)	Country of residence P value
	Agalactosylation	21.4	18.3	0.9	1.03 × 10-111
	Monogalactosylation	38.0	2.6	0.1	7.69 × 10-193
IgG1	Digalactosylation	18.6	21.7	1.1	3.51 × 10-98
	Sialylation	10.8	13.2	0.6	1.27 × 10-54
	Bisecting GlcNAc	18.6	17.5	0.0	9.28 × 10-110
	Agalactosylation	12.8	23.9	0.9	7.18 × 10-62
	Monogalactosylation	20.8	7.6	0.1	3.34 × 10-94
IgG2	Digalactosylation	10.4	27.5	1.1	2.70 × 10-54
	Sialylation	6.5	18.2	0.5	1.22 × 10-27
	Bisecting GlcNAc	12.4	11.9	0.1	3.66 × 10-64
	Agalactosylation	20.5	13.7	0.4	1.32 × 10-93
	Monogalactosylation	20.8	2.6	0.1	1.30 × 10-78
IgG4	Digalactosylation	18.2	14.1	0.8	1.28 × 10-86
	Sialylation	15.4	9.7	0.5	6.44 × 10-75
	Bisecting GlcNAc	7.6	15.7	0.6	2.01 × 10-37

Displayed values represent percentage (%) of glycan trait variability explained by country, age and sex.