Figure 3.

Protein activators of the APC that function through CDC20 and/or CDH1. The BioGRID database was searched for CDC20 and CDH1 interactors. All protein nodes identified were searched using PubMed. Proteins found to activate the APC, but not serve as substrates, are shown here. Proteins unique to CDC20 are shown in red, those unique to CDH1 are shown in blue, and those identified in both searches are shown in green. PARKIN, when phosphorylated by PLK1, is believed to recruit CDC20 and CDH1 to ubiquitinate APC substrates. Ph, phosphorylation; Ac, acetylation; Ub, ubiquitination.