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. 2020 Aug 15;12(15):15556–15565. doi: 10.18632/aging.103575

Table 3. Chromosomal microarray analysis using SNP array testing of samples with normal karyotypes.

Case Microarray nomenclature Size (Mb) Phenotypic characteristics of fetuses Pathogenicity classification Obstetric outcomes Inheritance
1 arr[hg19]22q11.21 (18,916,842-21,800,471) ×1 2.9 CHD P TP de novo
2 arr[hg19]22q11.21 (18,648,855-21,800,471) ×1 3.1 CHD P TP de novo
3 arr[hg19]22q11.21 (18,648,855-21,800,471) ×1 3.1 CHD, thymic dysplasia P TP de novo
4 arr[hg19]22q11.21 (18,649,189-21,800,471) ×1 3.1 CHD P TP de novo
5 arr[hg19]22q11.21 (18,648,855-21,800,471) ×1 3.1 CHD P TP de novo
6 arr[hg19]22q11.21 (20,730,143-21,800,471) ×1 1.0 Multiple cysts of left choroid plexus, left renal cysts, and varus P TP de novo
7 arr[hg19]17q12 (34,822,465-36, 404, 555) ×1 1.58 Double kidney echo enhancement P TP de novo
8 arr[hg19]17q12 (34,822,465-36, 243, 365) ×1 1.4 Double kidney echo enhancement P TP de novo
9 arr[hg19]17q12 (34,822,465-36, 307, 773) ×1 1.48 Double kidney echo enhancement P TP Maternal
10 arr[hg19]16p11.2 (28,810,324-29,032,280)×1 0.22 Lateral ventricle widens P TP de novo
11 arr[hg19]16p11.2 (29,567,296-30,190,029)×1 0.6 Lateral ventricle widens P TP de novo
12 arr[hg19]16p11.2 (29,591,326-30,176,508)×1 0.57 Hydrocephalus P TP de novo
13 arr[hg19]3q29 (195,743,957-197,386,180) ×3 1.6 VSD P TP de novo
14 arr[hg19]4p16.3 p16.1 (68,345-6,608,624)×1 6.5 CHD P TP de novo
15 arr[hg19]5q35.2q35.3 (175,416,095-177,482, 506) ×1 2.0 Lateral ventricle widens P TP de novo
16 arr[hg19]7q11.23 (72,723,370-74,143,240)×1 1.42 FGR P TP de novo
17 arr[hg19]7q11.23 (72,701,098-74,069,645)×3 1.3 VSD, Unilateral renal agenesis P TP de novo
18 arr[hg19]10q11.22q11.23 (46,252,072-51,903,756) ×1 5.6 FGR P TP de novo
19 arr[hg19]15q14q21.3 (35,077,111-54,347,324)hmz 19.2 FGR P TP UPD
20 arr[hg19]15 q13.3 (32,011,458-32,914,239)×3 0.88 Half vertebral body P TP Paternal
21 arr[hg19]17p12 (14,083,054-15,482,833) ×1 1.4 Left renal dysplasia P TP Maternal
22 arr[hg19]15q11.2 (22,770,421-23,277,436)×1 1.2 VSD, Brain dysplasia P TP paternal
23 arr[hg19]17p13.3p13.2 (525-5,204,373)×1 5.2 Bilateral ventricles widened, cerebellum entricular dysplasia P TP de novo
24 arr[hg19]22q13.33 (49,683,904-51,197,766) ×1 3.1 Echogenic bowel P TP de novo
25 arr[hg19]16p13.11 (15,510,512-16,309,046)×3 0.78 Tricuspid regurgitation VOUS TD -
26 arr[hg19]1q21.1 (145,375,770-145,770,627)×1,9p24.1 (4,623,660-5,501,699) ×3 0.68,0.86 Lateral ventricle widens VOUS TD de novo
27 arr[hg19]1q21.1q21.2 (145,995,176-147,398,268)×3 1.4 CHD VOUS TP de novo
28 arr[hg19]1q21.1q21.2 (145,958,361-147,830,830)×3 1.8 Lateral ventricle widens VOUS TD de novo
29 arr[hg19]2q22.2 (143,043,284-143,866,399)×4 0.80 Effusion VOUS TD de novo
30 arr[hg19]2q36.1q36.2 (224,459,152-225,330,583)×3 0.85 Posterior fossa widened VOUS TD de novo
31 arr[hg19]2q11.1q11.2 (96,679,225-97,669,032)×1 0.97 Hydronephrosis VOUS TD de novo
32 arr[hg19]3p26.3 (1,855,754-2,663,625)×1 0.79 Bilateral ventricles widened VOUS TD -
33 arr[hg19]3q26.1q29(163,256,369-197,791,601)hmz,5p13.1p11 (41,029,137-46,313,469)hmz,6q24. 2q25(143,341,406-161,527,784) hmz,12q13.2q21.2(56,011,100-77,134,151)hmz,17q21.2q21.32(39,639,602-45,479,706)hmz,21q21. 3q22.2(28,124,165-42,352,287)hmz 99.1 Lateral ventricle widens VOUS TD -
34 arr[hg19]3p22.1 (42,875,130-43,309,436)×1 0.42 Lateral ventricle widens VOUS TD de novo
35 arr[hg19]3q28(188,788,120-191,331,505) ×1,15q11.2(23,620,191-24,978,547) ×3 2.5 Unilateral renal agenesis VOUS TD de novo
36 arr[hg19]3p22.3 (33,805,560-35,318,562)×3 1.5 Effusion VOUS TD Maternal
37 arr[hg19]5p15.33p15.31 (4,482,234-6,636,035)×1 0.61 Effusion VOUS TP de novo
38 arr[hg19]4q28.3q31.3 (133,718,289-154,569,367)hmz 20.8 FGR VOUS TD de novo
39 arr[hg19]4q24(106,284,925-107,545,257)×3 1.2 VSD VOUS TD de novo
40 arr[hg19]8p23.2(3,703,883-5,940,433) ×3 2.2 Bilateral choroid plexus cysts VOUS TD de novo
41 arr[hg19]10q24.31Q24.32 (102,972,457-103,179,063)×3 0.20 Posterior fossa widened VOUS TD de novo
42 arr[hg19]10q11.21q11.22 (42,433,738-48,006,310) ×1 5.5 Echogenic bowel VOUS TD de novo
43 arr[hg19]13q14.3 (52,649,105-53,172,866) ×3 0.53 Hydronephrosis VOUS TD de novo
44 arr[hg19]14q21.2q21.3 (46,782,405-49,288,860) ×1 2.5 Hydrocephalus VOUS TP de novo
45 arr[hg19]15q11.2 (22,770,421-23,082,237)×1 0.30 Ultrasound soft markers VOUS TD de novo
46 arr[hg19]15q11.2 (22,770,421-23,286,423)×1 0.5 Ultrasound soft markers VOUS TD Paternal
47 arr[hg19]15 q13.3 (31,999,631-32,444,043)×3 0.43 Severe hydrocephalus VOUS TP de novo
48 arr[hg19]15 q13.3 (32,003,537-32,444,043)×3 0.43 CHD VOUS TP de novo
49 arr[hg19]16p13.11 (15,325,072-16,272,403)×3 0.92 Bilateral hydronephrosis VOUS TP de novo
50 arr[hg19]16p13.11 (15,171,146-16,309,046)×3 1.1 Echogenic bowel VOUS TD Maternal
51 arr[hg19]16p13.11 (14,897,401-16,534,031)×1 1.6 VSD VOUS TD de novo
52 arr[hg19]16p11.2 (29,580,020-30,190,029)×1 0.60 Spinal dysplasia VOUS TP de novo
53 arr[hg19]17q21.31 (41,774,473-42,491,805)×4 0.70 FGR VOUS TD de novo
54 arr[hg19]22q11.21 (18,648,855-21,459,713) ×3 2.8 CHD VOUS TP Maternal
55 arr[hg19]22q11.21 (18,648,855-21,800,471) ×3 3.1 FGR VOUS TD Paternal
56 arr[hg19]Xp21.1 (32,670,116-32,891,702) ×1 0.22 Effusion VOUS TD de novo

CHD: Congenital heart disease; FGR: fetal growth restriction; NIPT noninvasive prenatal testing; P: pathogenic; TD: term delivery; TP: termination of pregnancy; UPD: uniparental disomy; VSD: ventricular septal defect.