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Improved mitochondrial dynamics depend on Nrf2 translocation (n = 8). Mice in co-treatment group were treated with brustatol 24h prior LPS challenge in i.p.. The mitoSox red (Bar = 50 μm) (A); expressions of total and nuclear Nrf2, VDAC1 and Cyt c (B), OPA1 and Drp1, Bax and caspase-3 and semi-quantification (C). #P ≤ 0.05, ##P ≤ 0.01 compared to control mice; *P ≤ 0.05, **P ≤ 0.01 compared to LPS challenged alone; ▲P ≤ 0.05, ▲▲P ≤ 0.01 between PB2 and PB2+BT.
