Table 4. Univariate and multivariate analysis of risk factors of severe cases in Guangzhou.
| Univariable OR (95% CI) | P value | Multivariable OR (95%) CI) | P value | |
| Demographics and clinical characteristics | ||||
| Age, years | 1.063(1.033-1.095) | <0.0001 | 1.057 (1.018-1.098) | 0.004 |
| Female sex (vs male) | 0.605(0.282-1.298) | 0.197 | .. | .. |
| Comorbidity present (vs not present) | ||||
| Hypertension | 2.739(1.272-5.898) | 0.010 | .. | .. |
| COPD | 6.296(1.007-39.354) | 0.049 | .. | .. |
| CVD | 2.686(1.248-5.780) | 0.012 | 0.986(0.052-18.588) | 0.992 |
| CKD | 9.769(2.307-41.376) | 0.002 | 6.966(1.310-37.058) | 0.023 |
| Respiratory rate >24 breaths per min | 6.239(2.238-17.397) | <0.0001 | .. | .. |
| Exposure history in Wuhan >2 weeks | 2.607(1.174-5.791) | 0.019 | 2.765(1.040-7.355) | 0.042 |
| Fever (tempetature≥37·3°C) | 4.345(1.282-14.730) | 0.018 | .. | .. |
| Nausea or Anorexia | 2.682(0.991-7.258) | 0.052 | .. | .. |
| Diarrhea | 8.400(2.392-29.494) | 0.001 | 24.349(3.580-165.609) | 0.001 |
| Laboratory and radiography findings | ||||
| White blood cell count (109/L) (No (%)): | .. | .. | .. | .. |
| ≤4 | 0.910(0.325-2.543) | 0.857 | 0.968(0.289-3.245) | 0.958 |
| 4-10 | 1(ref) | .. | .. | .. |
| ≥10 | 15.553(4.032-59.988) | <0.0001 | 5.776(1.052-31.722) | 0.044 |
| Lymphocyte count (×109/L) | .. | .. | .. | .. |
| <1.1 | 0.263(0.121-0.573) | 0.001 | 0.697(0.246-1.975) | 0.497 |
| Hemoglobin (g/L) | 0.966(0.946-0.986) | 0.001 | .. | .. |
| Platelet count (×109/L) | 0.993(0.987-1.000) | 0.042 | .. | .. |
| D-dimer (mg/L) | .. | .. | .. | .. |
| ≤1000 | 1(ref) | .. | .. | .. |
| >1000 | 1.947(0.859-4.416) | 0.111 | .. | .. |
| ALT (U/L) | .. | .. | .. | .. |
| ≤50 | 1(ref) | .. | .. | .. |
| >50 | 2.604(1.022-6.634) | 0.045 | .. | .. |
| AST(U/L) | .. | .. | .. | .. |
| ≤40 | 1(ref) | .. | .. | .. |
| >40 | 3.545(1.425-8.823) | 0.007 | .. | .. |
| Myoglobin (μg/L) | .. | .. | .. | .. |
| ≤106 | 1(ref) | .. | .. | .. |
| >106 | 33.682(6.413-176.905) | <0.0001 | 8.910(1.225-64.816) | 0.031 |
| Creatinine (μmol/L) | .. | .. | .. | .. |
| ≤106 | 1(ref) | .. | .. | .. |
| >106 | 4.667(1.104-19.728) | 0.036 | .. | .. |
| Creatinine kinase (U/L) | .. | .. | .. | .. |
| ≤310 | 1(ref) | .. | .. | .. |
| >310 | 9.107(1.234-67.188) | 0.030 | .. | .. |
| CRP (mg/L) | .. | .. | .. | .. |
| ≤10 | 1(ref) | .. | .. | .. |
| >10 | 7.596(2.995-19.264) | <0.0001 | 5.362(1.631-17.626) | 0.006 |
| PCT (ng/mL) | .. | .. | .. | .. |
| ≤0.05 | 1(ref) | .. | .. | .. |
| >0.05 | 5.333(1.572-18.098) | 0.007 | .. | .. |
| BNP (ng/L) | 1.022(1.005-1.040) | 0.014 | .. | .. |
| TNI (μg/L) | .. | .. | .. | .. |
| ≤0.03 | 1(ref) | .. | .. | .. |
| >0.03 | 12.231(4.14-36.131) | <0.0001 | .. | .. |
| Bilateral pneumonia | 6.292(0.836-47.378) | 0.074 | .. | .. |
OR=odds ratio.
*P values indicate differences between Severe and Non-severe patients. P<0.05 was considered statistically significant.