Table 3.

Determination of bioequivalence test method for acetylsalicylic acid

Parameter	SWR	CVWR	Reference scaled average bioequivalence conclusion
log (Cmax)	0.721	0.826	RSABE applicable (SWR ≥ 0.294)
log (AUClast)	0.472	0.500	RSABE applicable (SWR ≥ 0.294)
log (AUC)	0.406	0.424	RSABE applicable (SWR ≥ 0.294)

CV_WR calculated for raw pharmacokinetic parameters, AUC area under the plasma concentration versus time, C_max maximum plasma concentration observed, AUC_last area under the plasma concentration versus time curve calculated using the trapezoidal method from time zero to the real time