Table 4.

Formulation effect on C_max, AUC_last, and AUC for acetylsalicylic acid in test versus reference

Parameter	Estimate	Acetylsalicylic acid*	Clopidogrel#
		95% CI for (μT − µR)2 – θ${\sigma }_{\text{WR}}^2$	Estimate	90% CI
Cmax	1.19	− 0.30	1.11	1.05–1.18
AUClast	1.09	− 0.14	0.95	0.91–0.99
AUC	1.04	− 0.10	0.96	0.92–1.00

AUC area under the plasma concentration versus time, C_max maximum plasma concentration observed, AUC_last area under the plasma concentration versus time curve calculated using the trapezoidal method from time zero to the real time

*Point estimates of formulation ratios and upper one-sided 95% confidence interval for the reference scaled average bioequivalence metrics (S_WR ≥ 0.294); upper 95% CI for (μ_T − µ_R)² − θ${\sigma }_{\text{WR}}^2$θ = [ln (1.25)/σ₀]² with σ₀ = 0.250 corresponding to a regulatory constant

^#Point estimates of formulation ratios with 90% CIs using average bioequivalence analysis