Table 1.

European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) LDL-C targets for high/very high-risk groups

Clinical risk categories	Target LDL-C levels
Established CVD	LDL-C < 1.8 mmol/L or 50% reduction in LDL-C
DM with target organ damage	LDL-C < 1.8 mmol/L or 50% reduction in LDL-C
FH	LDL-C < 2.5 mmol/L or maximal reduction in LDL-C with any possible drug combination plus LDL apheresis
SCORE ≥ 10% considered very high risk, SCORE 5–10% considered high risk	Very high risk, LDL-C < 1.8 mmol/L or 50% reduction in LDL-C; high risk, LDL-C < 2.5 mmol/L

CVD cardiovascular disease, LDL-C low-density lipoprotein cholesterol, DM diabetes mellitus, FH familial hypercholesterolaemia, SCORE Systematic COronary Risk Evaluation calculates 10-year risk of fatal cardiovascular disease as a percentage