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. 2020 Sep 1;8(2):e001326. doi: 10.1136/jitc-2020-001326

Figure 5.

Figure 5

Recurrent tumors display impaired inflammatory myeloid cell infiltration. (A–E) The scheme of the experiment is shown in figure 4A. The mice (group 1–4) were sacrificed on day 15 post-tumor challenge. (A) The percentage of CD11b+, classII+CD11b+ and Ly6ChiCD11b+ cells within live gate in the tumor microenvironment of untreated and suboptimal SLP-vaccinated TC-1 and TC-1 recurrent tumor-bearing mice. (B) The percentage of M1-type macrophages, CD11c+ DCs and pDCs within live gate. (C) The percentage of intratumoral Ly6G+ neutrophils and M2-type macrophages within live gate. (D) The expression level of IRF-1 on intratumoral CD11b+ myeloid cells. The representative histogram is shown on the right. (E) The normalized gene expression level of TNF in the tumor microenvironment of untreated and SLP-vaccinated TC-1 and TC-1 recurrent tumor-bearing mice. Data presented are mean±SEM in the scatter plot and min to max (mean shown as +) in box and whiskers plots. Statistical analysis was performed using unpaired t-test. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. ns, not significant; TNF, tumor necrosis factor.