Table 2. Drug-Loaded Lignin NCs According to Cross-Linkers Utilizeda.
| entry | drug | drug/mg·mL–1 | cross-linker | Dp/nm | PDI | EE/% |
|---|---|---|---|---|---|---|
| AE01 | azoxystrobin | 2 | EDBEA | 190 | 0.17 ± 0.06 | 88 |
| AS01 | 2 | spermidine | (470) | (0.33 ± 0.09) | 99 | |
| BE01 | boscalid | 1 | EDBEA | 210 | 0.12 ± 0.03 | 77 |
| BS01 | 1 | spermidine | 225 | 0.14 ± 0.03 | 98 | |
| PE01 | pyraclostrobin | 2 | EDBEA | 206 | 0.3 ± 0.1 | 93 |
| PS01 | 2 | spermidine | (535 ± 155) | (0.4 ± 0.1) | >99 | |
| TE01 | tebuconazole | 2 | EDBEA | 165 | 0.19 ± 0.04 | 73 |
| TS01 | 2 | spermidine | 300 | 0.2 ± 0.1 | 97 |
a
Average particle size (Dp) and PDI measured by DLS (measurements presented as mean ± SD of triplicates; values in brackets exhibited some aggregation) and EE measured by HPLC. Sample nomenclature: first letter denotes the drug (A = azoxystrobin, B = boscalid, P = pyraclostrobin, T = tebuconalzole; second letter denotes the cross-linker: E = EDBEA, S = spermidine, number = number of sample).