Table 4.
Diagnostic predictiveness (bias, precision and accuracy stratified by eGFR) in CKD cohorts
| eGFRCKD-EPI | Number | Age (years) | BMI (kg/m2) | Equation | Bias (mL/min/1.73 m2) | Precision (mL/min/1.73 m2) | Absolute error (%) | P30 (%) |
|---|---|---|---|---|---|---|---|---|
| <30 | 1504 | 72 | 27 | CKD-EPI | −0.3 (−0.7, 0.0) | 6.8 (6.4–7.2) | 18.1 (16.8–18.9) | 74.5 (72.3–76.7) |
| FAS | 2.0 (1.6–2.2) | 7.0 (6.7–7.4) | 19.6 (18.2–20.8) | 68.4 (66.1–70.8) | ||||
| LMR | −1.1 (−1.4, −0.8) | 6.7 (6.4, 7.2) | 17.8 (17.0–18.6) | 77.1 (75.0–79.3) | ||||
| 30–59 | 2419 | 65 | 27 | CKD-EPI | 1.6 (1.2–2.1) | 12.5 (11.9–13.3) | 15.3 (14.7–16.0) | 78.6 (77.0–80.3) |
| FAS | 1.9 (1.5–2.4) | 13.5 (13.0–14.2) | 15.8 (15.2–16.6) | 76.6 (74.9–78.3) | ||||
| LMR | −1.8 (−2.4, −1.4) | 12.6 (11.9–13.1) | 15.7 (14.9–16.4) | 81.1 (79.5–82.7) | ||||
| 60–89 | 2130 | 58 | 25 | CKD-EPI | 6.5 (5.6–7.2) | 19.7 (18.9–20.8) | 15.8 (14.8–16.6) | 76.3 (74.5–78.1) |
| FAS | 1.8 (1.0–2.7) | 19.7 (18.7–20.7) | 14.0 (13.3–14.5) | 82.1 (80.5–83.7) | ||||
| LMR | −0.7 (−1.4, 0.0) | 18.8 (18.0–19.9) | 13.8 (13.2–14.3) | 84.0 (82.4–85.5) | ||||
| 90–119 | 1578 | 46 | 24 | CKD-EPI | 10.1 (9.2–11.2) | 21.2 (20.2–22.4) | 13.6 (12.7–14.6) | 80.4 (78.5–82.4) |
| FAS | 7.3 (6.4–8.0) | 21.8 (20.5–23.2) | 12.6 (12.1–13.4) | 81.6 (79.6–83.5) | ||||
| LMR | −2.8 (−3.7, −1.8) | 20.8 (19.7–22.0) | 11.7 (11.1–12.3) | 90.1 (88.6–91.6) | ||||
| ≥120 | 734 | 21 | 21 | CKD-EPI | 22.5 (20.6–23.8) | 24.3 (22.3–25.8) | 21.1 (19.2–22.5) | 67.0 (63.6–70.4) |
| FAS | 20.4 (17.9–22.3) | 33.7 (30.7–37.1) | 19.6 (17.7–21.9) | 65.8 (62.4–69.2) | ||||
| LMR | −0.6 (−2.9, 1.1) | 25.2 (22.9–27.4) | 11.2 (10.6–12.4) | 88.7 (86.4–91.0) |
Estimation results for CKD-EPI, FAS and LMR (95% CI) stratified by eGFR (mL/min/1.73 m2) based on the CKD-EPI equation (eGFRCKD-EPI). The best result for each performance marker is marked with bold and italic in each stratum. Number of patients, median age (years) and BMI (kg/m2) are given in each stratum Median bias (eGFR − mGFR) and precision (IQR) expressed in mL/min/1.73 m2. Absolute error expressed as median absolute percentage error |eGFR − mGFR|/mGFR, and P10 and P30 accuracy (percentage of GFR estimates within 10% and 30% of mGFR).