Table 5.
Diagnostic predictiveness (bias, precision and accuracy stratified by eGFR) in community cohorts
| eGFRCKD-EPI | Number | Age (years) | BMI (kg/m2) | Equations | Bias (mL/min/1.73 m2) | Precision (mL/min/1.73 m2) | Absolute error (%) | P30 (%) |
|---|---|---|---|---|---|---|---|---|
| <60a | 473 | 78 | 27 | CKD-EPI | −0.2 (−1.2, 0.6) | 12.8 (12.2–14.5) | 13.7 (12.2–15.5) | 83.7 (80.4–87.1) |
| FAS | −4.3 (−5.0, −3.4) | 12.2 (10.7–13.9) | 13.9 (12.8–15.5) | 85.4 (82.2–88.6) | ||||
| LMR | −4.5 (−5.2, −3.3) | 11.9 (10.9–13.8) | 15.1 (13.8–16.1) | 82.5 (79.0–85.9) | ||||
| 60–89 | 2479 | 63 | 27 | CKD-EPI | 1.0 (0.4–1.7) | 18.2 (17.3–19.0) | 11.6 (11.1–12.2) | 85.7 (82.4–89.0) |
| FAS | −5.8 (−6.2, −5.2) | 15.5 (14.8–16.3) | 11.7 (11.2–12.2) | 92.7 (91.6–93.7) | ||||
| LMR | −7.1 (−7.6, −6.5) | 16.3 (15.5–17.1) | 12.4 (12.0–12.9) | 91.4 (90.3–92.5) | ||||
| 90–119 | 3687 | 55 | 26 | CKD-EPI | 3.0 (2.6–3.6) | 17.0 (16.4–17.7) | 9.2 (8.9–9.7) | 88.9 (87.6–90.1) |
| FAS | 2.2 (1.7–2.7) | 18.4 (17.7–19.2) | 9.6 (9.2–10.0) | 92.9 (92.1–93.7) | ||||
| LMR | −7.0 (−7.6, −6.5) | 17.2 (16.6–17.8) | 10.7 (10.3–11.0) | 94.8 (94.0–95.5) | ||||
| ≥120 | 120 | 29 | 23 | CKD-EPI | 12.9 (6.9–15.6) | 18.7 (15.4–22.5) | 12.8 (10.7–15.6) | 92.5 (87.7–97.3) |
| FAS | 19.3 (15.5–23.2) | 26.8 (20.5–29.7) | 16.3 (14.0–21.9) | 73.3 (65.3–81.4) | ||||
| LMR | −4.5 (−7.9, −1.8) | 19.1 (16.0–23.9) | 9.6 (8.6–10.6) | 98.3 (94.1–99.8) |
Estimation results for CKD-EPI, FAS and LMR (95% CI) stratified by eGFR (mL/min/1.73 m2) based on the CKD-EPI equation (eGFRCKD-EPI). The best result for each performance marker is marked with bold and italic in each stratum. Number of patients, median age (years) and BMI (kg/m2) are given in each stratum Median bias (eGFR − mGFR) and precision (IQR) expressed in mL/min/1.73 m2. Absolute error expressed as median absolute percentage error |eGFR − mGFR|/mGFR, and P10 and P30 accuracy (percentage of GFR estimates within 10% and 30% of mGFR). amGFR intervals <44 were collapsed with 45–59 due to small numbers (<100).