Table 6.
Diagnostic predictiveness (bias stratified for eGFR) in CKD and community cohorts
| CKD cohorts |
Community cohorts |
|||||
|---|---|---|---|---|---|---|
| CKD-EPI | FAS | LMR | CKD-EPI | FAS | LMR | |
| Constanta | 1.9 (0.6 – 3.2) | 5.8 (4.6 – 7.1) | −2.3 (−3.5, −1.1) | −10.4 (−12.5, −8.3) | −7.7 (−9.9, −5.4) | −16.7 (−18.8, −14.7) |
| eGFRCKD-EPI | ||||||
| <30 | Reference | Reference | Reference | −b | −b | −b |
| 30 – 59 | 2.0 (1.0 – 3.0) | −0.8 (−1.8, 0.2) | −0.8 (−1.7, 0.2) | Reference (<60) | Reference (<60) | Reference (<60) |
| 60 – 89 | 6.7 (5.6 – 7.7) | −1.3 (−2.4, −0.3) | 0.2 (−0.8, 1.3) | 6.1 (4.6 – 7.7) | 0.7 (−0.9, 2.4) | 0.7 (−0.8, 2.2) |
| 90 – 119 | 10.1 (8.9 – 11.3) | 3.2 (2.0 – 4.4) | −1.4 (−2.6, −0.3) | 11.8 (10.1 – 13.4) | 9.9 (8.1 – 11.7) | 3.6 (2.0 – 5.2) |
| ≥120 | 19.5 (17.9 – 21.1) | 14.4 (12.8 – 16.0) | 0.2 (−1.3, 1.8) | 22.4 (19.2 – 25.7) | 26.3 (22.8 – 29.8) | 10.1 (6.9 – 13.3) |
| Age | ||||||
| <40 | Reference | Reference | Reference | Reference | Reference | Reference |
| 40 – 59 | −2.8 (−3.8, −1.7) | 0.2 (−0.9, 1.2) | 1.9 (0.9 – 2.9) | −0.7 (−2.0, 0.7) | −0.4 (−1.8, 1.0) | 3.4 (2.1 – 4.7) |
| 60 – 69 | −1.1 (−2.2, 0.1) | −1.9 (−3.1, −0.8) | 2.6 (1.6 – 3.7) | 2.5 (1.0 – 3.9) | −1.1 (−2.7, 0.4) | 5.7 (4.3 – 7.2) |
| ≥70 | 0.1 (−1.0, 1.2) | −3.0 (−4.0, −1.9) | 2.6 (1.5 – 3.6) | 10.0 (8.3 – 11.7) | 3.3 (1.5 – 5.1) | 11.0 (9.4 – 12.7) |
| Female | −0.3 (−1.0, 0.3) | −1.3 (−1.9, −0.6) | 0.2 (−0.4, 0.8) | 2.6 (1.9 – 3.3) | 1.0 (0.3 – 1.8) | 4.2 (3.5 – 4.8) |
| BMI | ||||||
| <18.5 | 6.9 (5.4 – 8.4) | 6.8 (5.3 – 8.3) | 6.8 (5.4 – 8.2) | −1.6 (−3.6, 0.3) | −0.9 (−3.0, 1.2) | −1.5 (−3.4, 0.4) |
| 18.5 – 24.9 | Reference | Reference | Reference | Reference | Reference | Reference |
| 25.0 – 29.9 | −2.2 (−3.0, −1.4) | −1.9 (−2.7, −1.1) | −1.9 (−2.7, −1.2) | 0.0 (−0.9, 0.8) | −0.2 (−1.1, 0.7) | −0.0 (−0.8, 0.8) |
| ≥30.0 | −2.5 (−3.4, −1.6) | −2.0 (−2.9, −1.1) | −2.1 (−2.9, −1.2) | −0.1 (−1.0, 0.9) | −0.1 (−1.1, 0.9) | 0.2 (−0.8, 1.1) |
Multivariable quantile regression estimates of median bias (mL/min/1.73 m2; 95% CI) by cohort type and subgroups of eGFR (mL/min/1.73 m2) according to the CKD-EPI equation (eGFRCKD-EPI), age (years), sex and BMI (kg/m2). The following example illustrates how to interpret the table by using CKD-EPI in the CKD cohort: a female (bias 1.9 − 0.3) aged 45 (bias −2.8) with a BMI of 17 (bias 6.9) and an eGFR of 125 (bias 19.5) results in an estimated eGFR with a bias of 1.9 – 0.3 – 2.8 + 6.9 + 19.5 = 25.2 mL/min/1.73 m2.
The constant reflects the estimated bias for an individual that belong to the reference group in all four dimensions (eGFR, age, sex and BMI).
mGFR intervals <30 were collapsed with 30 – 59 due to small numbers.