Figure 1.

A) Cartoon representation of human soluble epoxide hydrolase (sEH). This protein is formed by an N- and a C-lobe connected through a long linker. In the C-lobe the regions directly related to the large binding pocket are highlighted in yellow. B) The volume of the binding cavity is shown colored in cyan for the right-hand side (RHS), orange for the narrow tunnel, and purple for the left-hand side (LHS) pockets. C) C-lobe of sEH is shown in gray cartoon interacting with a fragment that contains a urea-like motif in yellow sticks (Protein Data Bank (PDB) code: 5ai5). The residues surrounding the binding cavity are shown as sticks. The main interactions between the protein and the ligand are indicated with dashed lines.