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. Author manuscript; available in PMC: 2020 Sep 2.
Published in final edited form as: J Cogn Neurosci. 2018 Jun 19;30(10):1452–1472. doi: 10.1162/jocn_a_01300

Table 1.

Statistical Mediators of pIPC–hippocampal Functional Connectivity Identified from the fMRI Study

x y z t Value Region Replicate Mediation Effect in TMS Group Correlation after Controlling for Region
9 −52 13 9.21 R RSC t = 8.3 (p = 5 × 10−8) r = .27 (p = .22)
31 −32 −15 8.34 R PHC t = 2.9 (p = .008) r = .09 (p = .70)
−25 −36 −12 8.1 L PHC t = 4.30 (p = .0003) r = .12 (p = .59)
59 −4 −18 6.46 R anterior temporal cortex t = 7.9 (p = 1 × 10−7) r = .48 (p = .023)
42 −55 31 6.3 R IPC t = 8.0 (p = 9 × 10−8) -
−48 −70 32 6.11 L IPC t = 6.5 (p = 2 × 10−6) -
24 32 49 6.02 R superior frontal sulcus t = 5.5 (p = 2 × 10−5) r = .64 (p = .001)
−14 −69 23 5.67 L parieto-occipital sulcus t = 5.4 (p = 2 × 10−5) r = .45 (p = .037)
7 62 12 5.63 R medial pFC t = 4.6 (p = .00015) r = .46 (p = .031)
−19 24 50 5.42 L superior frontal sulcus t = 4.7 (p = .00011) r = .56 (p = .007)
−33 31 1 5.26 L inferior frontal sulcus t = 1.7 (p = .10) r = .45 (p = .037)
35 47 27 5.1 R MFG t = 1.8 (p = .085) r = .40 (p = .064)
56 14 −2 4.9 R frontal operculum t = 0.32 (p = .76) -
6 31 −11 4.61 R ventromedial pFC t = 5.16 (p = 4 × 10−5) r = .51 (p = .015)
−63 −1 −16 4.6 L anterior temporal cortex t = 5.2 (p = 4 × 10−5) r = .56 (p = .006)

Peak coordinates are in MNI space. The “Replicate Mediation Effect in TMS Group” column presents results of the statistical mediation analysis of hippocampal–pIPC TMS site functional connectivity in TMS participants. Right column indicates the correlation between TMS-related associative memory changes and hippocampal–pIPC connectivity, after controlling for each region when estimating hippocampal–pIPC connectivity.