Table 2. Tdgf1 Heterozygosity Enhances EtOH-Induced HPE in Cdon^-/- Embryos.

Treatment	Genotype (# embryos with HPE/total (%))*
	Cdon+/-;Tdgf1+/-		Cdon-/-;Tdgf1+/+	Cdon-/-;Tdgf1+/-
Saline	0/23 (0%)		0/11 (0%)	2/27 (7.4%)
EtOH (2.9 g/kg)	1/48 (2.1%)		9/32 (28.1%)	31/56 (55.4%)**

* Crosses between the following genotypes were used to generate the genotypes scored above:.

Cdon^+/-;Tdgf1^+/- x Cdon^+/-;Tdgf1^+/-.

Cdon^+/-;Tdgf1^+/- x Cdo-^+/-;Tdgf1^+/-.

Cdon^+/- x Cdon^+/-;Tdgf1^+/-.

Cdon^+/- x Cdon^-/-;Tdgf1^+/-.

Cdon^-/- x Cdon^+/-;Tdgf1^+/-.

No HPE was found in offspring genotypes other than those shown.

** p=0.014 by Fisher's two-tailed exact test, when compared to EtOH-treated Cdon^-/-; Tdgf1 ^+/+ embryos.