Table 3. Lefty2 Heterozygosity Supresses EtOH-Induced HPE in Cdon^-/- Embryos.

Treatment	Genotype (# affected/total (%))*
	Total HPE		Single nostril
	Cdon-/-;Lefty2+/+	Cdon-/-;Lefty2+/-	Cdon-/-;Lefty2+/+	Cdon-/-;Lefty2+/-
Saline	1/12 (8.3%)	0/10 (0%)	0/12 (0%)	0/10 (0%)
EtOH (3.48 g/kg)	33/47 (70.2%)	26/48 (54.2%)	10/47 (21.3%)	3/48 (6.3%)**

* Crosses between the following genotypes were used to generate the genotypes scored above:.

Cdon^+/-;Lefty2^+/- x Cdon^+/-;Lefty2^+/-.

Cdon^+/-;Lefty2^+/- x Cdo-^+/-;Lefty2^+/-.

Cdon^+/- x Cdon^+/-;Lefty2^+/-.

Cdon^+/- x Cdo^-/-;Lefty2^+/-.

Cdon^-/- x Cdon^+/-;Lefty2^+/-.

No HPE was found in offspring genotypes other than those shown.

**p=0.04 by Fisher's two-tailed exact test, when compared to EtOH-treated Cdon^-/-;Lefty2^+/+ embryos with a single nostril.