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. 2020 Sep 2;9:e58737. doi: 10.7554/eLife.58737

Figure 5. Model of mTOR regulation of oRG morphology.

Figure 5.

(A) Simplified model of mTOR signaling pathway activating the GTPases, CDC42 and RAC1 to regulate actin dynamics. (B) During normal development appropriate levels of mTOR signaling regulate oRG morphology, basal process length and migration behavior through activation of CDC42 and its targets, CFL1 and ACTR2. (C) When mTOR signaling is dysregulated the basal process is truncated and oRG cells have decreased levels of F-actin, CDC42, CFL1, and ACTR2. The oRG cells are mispositioned, the basal process does not reach the pial surface, and the glial scaffold is disrupted.