Table 2.
NEED4 (rs8032158) Genotypes and Allele Frequencies in Keloid Patients and Control Group
| NEDD4 (rs8032158) gene polymorphism | Patients (n=100) No (%) |
Controls (n=60) No (%) |
χ2 | P- value | OR (95% CI) |
|---|---|---|---|---|---|
| Genotypes | |||||
| -CC | 48 (48.0) | 16 (26.7) | 4.62 | 0.010 | NA |
| -TC | 42 (42.0) | 30 (50.0) | |||
| -TT | 10 (10.0) | 14 (23.3) | |||
| Alleles | (n=200) | (n=60) | |||
| -C | 138 (69.0) | 31 (51.7) | 9-61 | 0.002 | 2.08 (1.31-3-32) |
| -T | 62 (31.0) | 29 (48.3) | |||
| -CC vs TC+TT | 7.11 | 0.008 | 2.54 (1.27-5.08) | ||
| -TT vs TC+CC | 5.23 | 0.022 | 0.37 (0.15-0.89) | ||
| -CC vs TC | 4.2 | 0.040 | 2.14 (1.03-4.47) | ||
| -CC vs TT | 8.63 | 0.003 | 1.80 | ||
| -TT vs TC | 2.1 | 0.156 | 0.51 (0.20-0.89) | ||
Note: NEDD4: neural precursor cell expressed developmentally down-regulated protein 4. n: Number. χ2: Chi square test. OR: odds ratio. CI: confidence interval