Figure 6.

Time-dependent release of the DOX from miRNA-155-responsive MC-1 microcapsule (panel I) and from miRNA-124-responsive MC-2 microcapsule (panel II) driven by (i) 10 nM of miRNA in the presence of H₁ and in the absence of CDN “S”, (ii) 100 nM of miRNA in the presence of H₁ and in the absence of CDN “S”, (iii) 1 μM of miRNA in the presence of H₁ and in the absence of CDN “S”, (iv) 10 nM of miRNA in the presence of H₁ and in the presence of CDN “S”, (v) 50 nM of miRNA in the presence of H₁ and in the presence of CDN “S”, (vi) 500 nM of miRNA in the presence of H₁ and in the presence of CDN “S”, and (vii) 1 μM of miRNA in the presence of H₁ and in the presence of CDN “S”. Error bars derived from N = 3 experiments. It should be noted that the solid lines (i–vii) correspond to a fit of the experimental results to a first-order drug release profile (r = 0.9804 for MC-1 and r = 0.9882 for MC-2).