Figure 1.

(A) Schematic presentation of the evolved emergence, selection, and cascaded catalytic emergence of networks. (B) Schematic design of the compositions of the nucleic-acid-based constitutional dynamic networks coupled to two endonucleases that allow the biocatalytically triggered selection and cascaded emergence processes. Panels I and II - Schematic cleavage of the sequence-specific domains associated with constituents AB′ and CD′ by the endonucleases EcoRI and HindIII, respectively. Panel III - The cleavage of a fluorophore/quencher (F_i/Q_i)-functionalized substrate by the Mg²⁺-ion-dependent DNAzyme reporter unit associated with the respective constituent.