Table 1.

Model parameters.

Parameter	Value	Units	References
a	10−5	day−1	Robertson-Tessi et al. (2012)
C1	0.3	ng mL−1	Robertson-Tessi et al. (2012)
I1	0.4	ng mL−1	Robertson-Tessi et al. (2012)
I2	0.75	ng mL−1	Robertson-Tessi et al. (2012)
k2	1.2	Unitless	Robertson-Tessi et al. (2012)
k3	11	Unitless	Robertson-Tessi et al. (2012)
k4	0.33	Unitless	Robertson-Tessi et al. (2012)
M	107	Cell	Robertson-Tessi et al. (2012)
ME	3 × 106	Cell	Robertson-Tessi et al. (2012)
MH	6 × 106	Cell	Robertson-Tessi et al. (2012)
MR	1 × 106	Cell	Robertson-Tessi et al. (2012)
p1	1.8 × 10−8	ng mL−1 day−1 cell−1	Robertson-Tessi et al. (2012)
p2	1.1 × 10−7	ng mL−1 day−1 cell−1	Robertson-Tessi et al. (2012)
p3	1.4 × 10−8	ng mL−1 day−1 cell−1	Robertson-Tessi et al. (2012)
p4	1.3 × 10−10	ng mL−1 day−1 cell−1	Robertson-Tessi et al. (2012)
pC	1.7 × 10−5	ng mL−1 day−1 cell−1	Robertson-Tessi et al. (2012)
r0	0.9	day−1	Robertson-Tessi et al. (2012)
R1	2 × 107	Cell	Robertson-Tessi et al. (2012)
s	0.17	$\frac{\text{EC}}{\mathrm{\mu }\mathrm{m}}$	Cameron and Davis (2009)
S1	3.5	ng mL−1	Robertson-Tessi et al. (2012)
S2	2.9	ng mL−1	Robertson-Tessi et al. (2012)
S3	1.7	ng mL−1	Robertson-Tessi et al. (2012)
S4	0.9	ng mL−1	Robertson-Tessi et al. (2012)
V1	3.5	ng mL−1	Estimated
V2	2.9	ng mL−1	Estimated
V3	0.14	ng mL−1	Estimated
α1	23	day−1	Robertson-Tessi et al. (2012)
α2	16	day−1	Robertson-Tessi et al. (2012)
α3	9.9	day−1	Robertson-Tessi et al. (2012)
α4	1.9	day−1	Robertson-Tessi et al. (2012)
α5	5.1	day−1	Robertson-Tessi et al. (2012)
α6	2.1	day−1	Robertson-Tessi et al. (2012)
α7	0.022	day−1	Robertson-Tessi et al. (2012)
αA1	0.24	$\frac{\mathrm{n}\mathrm{g}}{\mathrm{\mu }\mathrm{m}*\mathrm{m}\mathrm{L}*\mathrm{d}\mathrm{a}\mathrm{y}}$	Cameron and Davis (2009)
αA2	1.92	$\frac{\mathrm{n}\mathrm{g}}{\mathrm{\mu }\mathrm{m}*\mathrm{m}\mathrm{L}*\mathrm{d}\mathrm{a}\mathrm{y}}$	Cameron and Davis (2009)
αV	3 × 10−6	$\frac{\text{ng}}{\text{mL}*\text{cell}*\text{day}}$	Cameron and Davis (2009)
αV2	3.7 × 10−2	$\frac{\text{ng}}{\text{mL}*\text{cell}*\text{day}}$	Estimated
αY	0.198	day−1	Cameron and Davis (2009)
γ1	0.69	day−1	Cameron and Davis (2009)
γB	0.8	day−1	Cameron and Davis (2009)
θA2	106	Cell	Cameron and Davis (2009)
θB	1	Unitless	Cameron and Davis (2009)
θEC	4	Unitless	Cameron and Davis (2009)
θV	7.5	$\frac{\mathrm{c}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{e}\mathrm{r}\mathrm{c}\mathrm{e}\mathrm{l}\mathrm{l}\mathrm{s}}{\mathrm{\mu }\mathrm{m}}$	Cameron and Davis (2009)
θVa	5.9 × 10−5	$\frac{\text{ng}}{\text{mL}*\text{EC}}$	Cameron and Davis (2009)
θY	6.8 × 10−6	$\frac{\text{ng}}{\text{mL}*\text{EC}}$	Cameron and Davis (2009)
λ	0.5	day−1	Robertson-Tessi et al. (2012)
λB	7.5	$\frac{\text{cancer}\text{cells}}{\mathrm{\mu }\text{m}}$	Cameron and Davis (2009)
δA	0.2	day−1	Robertson-Tessi et al. (2012)
δA1	0.072	day−1	Cameron and Davis (2009)
δA2	0.072	day−1	Cameron and Davis (2009)
δD	0.5	day−1	Robertson-Tessi et al. (2012)
δE	1.0	day−1	Robertson-Tessi et al. (2012)
δH	0.1	day−1	Robertson-Tessi et al. (2012)
δR	0.1	day−1	Robertson-Tessi et al. (2012)
δU	0.14	day−1	Robertson-Tessi et al. (2012)
δV	19.96	day−1	Cameron and Davis (2009)
δY	0.198	day−1	Cameron and Davis (2009)
δVa	0.033	day−1	Cameron and Davis (2009)
ρ	0.0033	$\frac{\text{ng}}{\text{mL}*\text{EC}}$	Cameron and Davis (2009)
τ	5 × 10−8	$\frac{\text{mL}}{\text{ng}*\text{day}}$	Cameron and Davis (2009)
τC	0.08	day	Robertson-Tessi et al. (2012)
τI	0.05	day	Robertson-Tessi et al. (2012)
τS	0.07	day	Robertson-Tessi et al. (2012)
ω	0.576	day−1	Cameron and Davis (2009)