Table 1.

Screening and enrolment eligibility criteria for SiVETs and non-SiVETs cohorts

SiVET cohort	Non-SiVET cohort
Inclusion At least 3 and no more than 18 months of follow up in the OBC1 or OBC2 HIV-1 negative and willing to undergo HIV testing Age 18 to 49 years Able and willing to provide written informed consent Able and willing to provide adequate locator information including physical address Willing and able to return for follow-up clinic visits Intending to reside in study area for at least 1 year Willing to undergo pregnancy testing Not breastfeeding and no intent for pregnancy in the next year Willing to use effective contraception during the study and at least 3 months after the last vaccination	Inclusion At least 3 months and no more than 18 months of follow up in OBC1 or OBC2 Still in active follow up in the OBCs HIV-1 negative and willing to undergo HIV testing
Exclusion History of severe allergic reaction to any substance An acute or chronic illness Contraindication for Hepatitis B vaccine Participation in another clinical trial Hepatitis B positive (only SiVET2)	Exclusion HIV positive

SiVET simulated vaccine efficacy trial, OBC observational cohort