Table 1.

Population, intervention, comparators, outcomes, and study design (PICOS) criteria employed in the systematic literature review

Population	Randomized and non-randomized interventional and comparative observational studies of patients with chemotherapy-refractory or intolerant (third-line) mCRC including treatment with SIR-Spheres Y-90 resin microspheres, TAS-102 (trifluridine/tipiracil), and regorafenib
Intervention	SIR-Spheres Y-90 resin microspheres
Comparators	TAS-102 (trifluridine/tipiracil) Regorafenib Best supportive care
Outcomes	Overall survival Progression-free survival Response Specific adverse events as reported
Study design	Comparative studies of SIRT with Y-90 resin microspheres, TAS-102, regorafenib, and best supportive care