Table 2.

List of follicular fluid miRNAs in relation with ART outcome

miRNA(s)	Alteration	Correlated with	Target pathway(s)	Reference(s)
let-7c, miR-122; miR-542-3p, miR-92a, miR-29a, miR-130b, miR-31-3p, miR-192, miR-210, miR-22, miR-503, miR-98	↓; ↑	Failed fertilization	ErbB, MAPK, TGF-β, AMPK, etc.	[9]
miR-130b, miR-92a	↑	Unfertilized oocyte	TGF-β, p53, FOXO, mTOR, notch, etc.	[9]
miR-16-5p, miR-222-3p, miR-425-3p, miR-454-5p; miR-16-1-3p, miR-1244, miR-206, miR-202-5p	↑	Abnormal; normal fertilized oocyte	TGF-β, WNT, MAPK, etc.	[10]
miR-382-5p, miR-127-3p, miR-425-3p	↑	Fertilization rate	-	[68]
miR-214, miR-454; miR-766-3p, miR-132-3p, miR-16-5p;, miR-197, miR-320a	↑	Top quality day 3 embryo	ErbB, mTOR, TGF-β, p53, etc.; MAPK; WNT	[9, 10, 69]
miR-888	↓	Top quality day 3 embryo	ErbB, mTOR, TGF-β, p53, etc.	[9]
miR-663b	↓	Day 3 embryo quality, viable blastocyst, expanded blastocyst	MAPK, WNT, TGF-β	[10, 71]
let-7b	↓	Blastocyst formation, expanded blastocyst	TGF-β	[8]
miR-451	↓	Diminished fertilization and embryo quality in endometriosis	WNT	[89]
miR-29a	↑	Clinical pregnancy	-	[8]