Table 3.

Neurometabolic diseases with alopecia and global developmental delay

Neurometabolic disease	Diagnostic approach
Hypothyroidism	T4, TSH
Vit D dependent rickets and receptor abnormalities	25-OH-Vit D and 1, 25(OH)2 vit D
Biotinidase deficiency	Biotinidase activity
Multiple carboxylase deficiency	Biotinidase, Acetyl-CoA carboxylase, Pyruvate carboxylase, MethylcrotonylCo A Carboxylase, Propionyl Co A Carboxylase